Protein Details: Glutamate receptor 2.2

Protein ID

ICDB_Pro_1629

Protein Name

Glutamate receptor 2.2

Gene Name

GLR2.2; At2g24720; F27A10.3

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

920 amino acids

AlphaFoldDB

AF-Q9SHV1-F1-model_v4.pdb

Function

Glutamate-gated receptor that probably acts as a non-selective cation channel. May be involved in light-signal transduction and calcium homeostasis via the regulation of calcium influx into cells.

Sequence

MKNSKLFFRFLFLFFFFCLESSRGQDNGKTQVNIGVVSDVGTSYPDVAMLCINMSLADFYSSRPQFQTRLVVNVGDSKNDVVGAATAAIDLIKNKQVKAILGPWTSMQAHFLIEIGQKSRVPVVSYSATSPSLTSLRSPYFFRATYEDSSQVHAIKAIIKLFGWREVVPVYIDNTFGEGIMPRLTDSLQDINVRIPYRSVIPLNATDQDISVELLKMMNMPTRVFIVHMSSSLASTVFIKAKELGLMKPGYVWILTNGVMDGLRSINETGIEAMEGVLGIKTYIPKSKDLETFRSRWKRRFPQMELNVYGLWAYDATTALAMAIEDAGINNMTFSNVDTGKNVSELDGLGLSQFGPKLLQTVSTVQFKGLAGDFHFVSGQLQPSVFEIVNMIGTGERSIGFWTEGNGLVKKLDQEPRSIGTLSTWPDHLKHIIWPGEAVSVPKGWEIPTNGKKLRIGVPKRIGFTDLVKVTRDPITNSTVVKGFCIDFFEAVIQAMPYDVSYEFFPFEKPNGEPAGNHNDLVHQVYLGQFDAVVGDTTILANRSSFVDFTLPFMKSGVGLIVPLKDEVKRDKFSFLKPLSIELWLTTLVFFFLVGISVWTLEHRVNSDFRGPANYQASTIFWFAFSTMVFAPRERVLSFGARSLVVTWYFVLLVLTQSYTASLASLLTSQQLNPTITSMSSLLHRGETVGYQRTSFILGKLNETGFPQSSLVPFDTAEECDELLKKGPKNGGVAAAFLGTPYVRLFLGQYCNTYKMVEEPFNVDGFGFVFPIGSPLVADVSRAILKVAESPKAVELEHAWFKKKEQSCPDPVTNPDSNPTVTAIQLGVGSFWFLFLVVFVVCVLALGKFTFCFLWKTKGKDLWKEFLKRDTDSYINDIEKCLCSQEMPENSNKATNQTNYGMELRVRNIVQVNQTDPDCL

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Expressed predominantly in roots

DOI ID

10.1093/oxfordjournals.molbev.a004165; 10.1038/45471; 10.1111/tpj.13415; 10.1126/science.292.5521.1486b

RefSeq

NP_180048.1